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Synthesis of Phenanthridinones from N‐ Methoxybenzamides and Arenes by Multiple Palladium‐Catalyzed CH Activation Steps at Room Temperature
Author(s) -
Karthikeyan Jaganathan,
Cheng ChienHong
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104311
Subject(s) - palladium , regioselectivity , catalysis , chemistry , combinatorial chemistry , simple (philosophy) , work (physics) , computer science , organic chemistry , physics , thermodynamics , philosophy , epistemology
Many steps make light work : Substituted phenanthridinones can be obtained with high regioselectivity and in very good yields by palladium‐catalyzed cyclization reactions of N ‐methoxybenzamides with arenes (see scheme). The reaction proceeds through multiple oxidative CH activation and CC/CN formation steps in one pot at room temperature, and thus provides a simple method for generating bioactive phenanthridinones.