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Synthesis of α‐Amino Acid Amides: Ruthenium‐Catalyzed Amination of α‐Hydroxy Amides
Author(s) -
Zhang Min,
Imm Sebastian,
Bähn Sebastian,
Neumann Helfried,
Beller Matthias
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104309
Subject(s) - amination , ruthenium , catalysis , chemistry , ammonia , organic chemistry , primary (astronomy) , combinatorial chemistry , physics , astronomy
Give me an N : The catalytic amination of α‐hydroxy amides with a variety of amines, including anilines, primary and secondary aliphatic amines, and ammonia, yields a wide range of α‐amino amides (see scheme). This atom‐efficient amination protocol proceeds efficiently in the presence of a commercially available [Ru 3 (CO) 12 ]/DCPE catalyst system.