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Direct Asymmetric α Benzoyloxylation of Cyclic Ketones
Author(s) -
Lifchits Olga,
Demoulin Nicolas,
List Benjamin
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104244
Subject(s) - amine gas treating , ketone , enantioselective synthesis , scheme (mathematics) , combinatorial chemistry , chemistry , cinchona , computer science , catalysis , organic chemistry , mathematics , mathematical analysis
It's amine business : A readily available cinchona‐derived primary amine is an effective catalyst for the direct asymmetric α benzoyloxylation of cyclic ketones (see scheme; Bz=benzoyl). This efficient and highly enantioselective method uses inexpensive benzoyl peroxide as the oxygen source and stoichiometric amounts of the ketone, and expands the current set of methodologies to directly access valuable protected 2‐hydroxyketone derivatives.