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Enantioselective Michael/Cyclization Reaction Sequence: Scaffold‐Inspired Synthesis of Spirooxindoles with Multiple Stereocenters
Author(s) -
Cao Yiming,
Jiang Xianxing,
Liu Luping,
Shen Fangfang,
Zhang Futing,
Wang Rui
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104216
Subject(s) - stereocenter , enantioselective synthesis , computer science , sequence (biology) , michael reaction , combinatorial chemistry , chemistry , catalysis , organic chemistry , biochemistry
A‐spiro‐ing : The title reaction of α‐isothiocyanato imides and methyleneindolinones has been realized for the first time using 1 as the catalyst. This newly developed synthetic method provides a simple, efficient, and environmentally friendly way to access, in an enantioselective manner, densely functionalized spirooxindoles having three contiguous stereogenic centers.