Enantioselective Michael/Cyclization Reaction Sequence: Scaffold‐Inspired Synthesis of Spirooxindoles with Multiple Stereocenters | Zendy

Cao Yiming | Zendy; Jiang Xianxing | Zendy; Liu Luping | Zendy; Shen Fangfang | Zendy; Zhang Futing | Zendy; Wang Rui | Zendy

Premium

Enantioselective Michael/Cyclization Reaction Sequence: Scaffold‐Inspired Synthesis of Spirooxindoles with Multiple Stereocenters

Author(s) -

Cao Yiming,

Jiang Xianxing,

Liu Luping,

Shen Fangfang,

Zhang Futing,

Wang Rui

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201104216

Subject(s) - stereocenter , enantioselective synthesis , computer science , sequence (biology) , michael reaction , combinatorial chemistry , chemistry , catalysis , organic chemistry , biochemistry

A‐spiro‐ing : The title reaction of α‐isothiocyanato imides and methyleneindolinones has been realized for the first time using 1 as the catalyst. This newly developed synthetic method provides a simple, efficient, and environmentally friendly way to access, in an enantioselective manner, densely functionalized spirooxindoles having three contiguous stereogenic centers.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research