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Back Cover: Artificial Molecular Clamp: A Novel Device for Synthetic Polymerases (Angew. Chem. Int. Ed. 33/2011)
Author(s) -
Takashima Yoshinori,
Osaki Motofumi,
Ishimaru Yoshihiro,
Yamaguchi Hiroyasu,
Harada Akira
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104186
Subject(s) - moiety , dimer , polymerase , polymerization , polymer , chemistry , clamp , cover (algebra) , dna polymerase , stereochemistry , polymer chemistry , combinatorial chemistry , dna , biochemistry , organic chemistry , computer science , engineering , clamping , computer vision , mechanical engineering
A synthetic polymerase including a cyclodextrin dimer is used to produce high‐molecular‐weight polymers. In their Communication on page 7524 ff., A. Harada and co‐workers report that one CD moiety (green) of the dimer acts as the active site of the polymerization, whereas the other moiety (purple) serves as an artifical molecular clamp that propagates the polymerization by holding the polymer chain (blue). This system is reminiscent of the DNA polymerase shown in the background of the picture.