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Site‐Specific p K a Determination of Selenocysteine Residues in Selenovasopressin by Using 77 Se NMR Spectroscopy
Author(s) -
Mobli Mehdi,
Morgenstern David,
King Glenn F.,
Alewood Paul F.,
Muttenthaler Markus
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104169
Subject(s) - selenocysteine , chemistry , nuclear magnetic resonance spectroscopy , spectroscopy , chemical shift , resolution (logic) , amino acid , amino acid residue , stereochemistry , cysteine , biochemistry , peptide sequence , enzyme , physics , computer science , gene , quantum mechanics , artificial intelligence
Selenocysteine (Sec), the 21st amino acid, is a component of a variety of proteins in all lineages of life, and the greater acidity of selenols compared to thiols provides Sec with unique chemical properties. By using 77 Se NMR spectroscopy the p K a of Sec residues in a protein could be measured at atomic resolution. This information can be used to predict chemical reactions.