Inhibition of Beta‐Amyloid Peptide Aggregation by Multifunctional Carbazole‐Based Fluorophores | Zendy

Yang Wanggui | Zendy; Wong Yi | Zendy; Ng Olivia T. W. | Zendy; Bai LiPing | Zendy; Kwong Daniel W. J. | Zendy; Ke Ya | Zendy; Jiang ZhiHong | Zendy; Li HungWing | Zendy; Yung Ken K. L. | Zendy; Wong Man Shing | Zendy

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Inhibition of Beta‐Amyloid Peptide Aggregation by Multifunctional Carbazole‐Based Fluorophores

Author(s) -

Yang Wanggui,

Wong Yi,

Ng Olivia T. W.,

Bai LiPing,

Kwong Daniel W. J.,

Ke Ya,

Jiang ZhiHong,

Li HungWing,

Yung Ken K. L.,

Wong Man Shing

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201104150

Subject(s) - cyanine , fibrillogenesis , carbazole , peptide , chemistry , biophysics , amyloid (mycology) , amyloid beta , alzheimer's disease , combinatorial chemistry , fibril , biochemistry , fluorescence , photochemistry , disease , medicine , biology , inorganic chemistry , physics , quantum mechanics

Stopping aggregation : Carbazole‐based cyanine fluorophores bind selectively to the Aβ (1–40) peptide and its aggregates which are responsible for causing Alzheimer's disease. One of these fluorophores, SLOH, exerts a strong inhibitory effect on Aβ (1–40) fibrillogenesis (see scheme) and can pass through the blood‐brain barrier making it a potential therapeutic agent for Alzheimer's disease.

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