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Ionic‐Surfactant‐Coated Burkholderia cepacia Lipase as a Highly Active and Enantioselective Catalyst for the Dynamic Kinetic Resolution of Secondary Alcohols
Author(s) -
Kim Hyunjin,
Choi Yoon Kyung,
Lee Jusuk,
Lee Eungyeong,
Park Jaiwook,
Kim MahnJoo
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104141
Subject(s) - kinetic resolution , lipase , burkholderia , enantioselective synthesis , chemistry , organic chemistry , biocatalysis , catalysis , ionic liquid , enzyme , combinatorial chemistry , biology , bacteria , genetics
With a coat for activity : A highly active enzyme was prepared by coating Burkholderia cepacia lipase with an ionic surfactant for use in dynamic kinetic resolution (DKR). Important features of this enzyme include: the fastest DKR of 1‐phenylethanol, the highly enantioselective DKR of a wide range of secondary alcohols (RCH(OH)Ar), and the switching of lipase enantioselectivity in DKR depending on the shape of the aliphatic chain (R).