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Indium Tribromide Catalyzed Cross‐Claisen Condensation between Carboxylic Acids and Ketene Silyl Acetals Using Alkoxyhydrosilanes
Author(s) -
Nishimoto Yoshihiro,
Okita Aya,
Yasuda Makoto,
Baba Akio
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104140
Subject(s) - ketene , silylation , claisen condensation , chemistry , catalysis , acetal , organic chemistry , aldol condensation , tribromide , condensation reaction , nitro , medicinal chemistry , condensation , carboxylic acid , indium , alkyl , physics , thermodynamics
Acylations achieved : The title reaction between carboxylic acids and ketene silyl acetals has been accomplished (see scheme). The additive, (MeO) 3 SiH, is believed to play an important role in the promotion of the condensation reaction. This reaction system was compatible with a diverse range of functional groups, including alkenes, alkynes, chlorides, alcohols, esters, and nitro groups.