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Proline‐Based P,O Ligand/Iridium Complexes as Highly Selective Catalysts: Asymmetric Hydrogenation of Trisubstituted Alkenes
Author(s) -
Rageot Denise,
Woodmansee David H.,
Pugin Benoît,
Pfaltz Andreas
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104105
Subject(s) - iridium , joins , catalysis , chemistry , ligand (biochemistry) , proline , asymmetric hydrogenation , combinatorial chemistry , organic chemistry , medicinal chemistry , enantioselective synthesis , computer science , amino acid , biochemistry , receptor , programming language
P,O joins the mix : P,O ligands ( L1 ) form efficient iridium catalysts for the asymmetric hydrogenation of olefins. The proline‐derived ligands lead to high enantioselectivities with several classes of alkenes, most notably with α,β‐unsaturated carboxylic esters and ketones, where they match or even surpass the ee values reported for the best N,P and C,N ligands.