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Regio‐ and Enantioselective Hydroamination of Dienes by Gold(I)/Menthol Cooperative Catalysis
Author(s) -
Kanno Osamu,
Kuriyama Wataru,
Wang Z. Jane,
Toste F. Dean
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104076
Subject(s) - hydroamination , enantioselective synthesis , menthol , chemistry , cationic polymerization , catalysis , selectivity , organic chemistry , alcohol
Alcohol is key : Regio‐ and enantioselective hydroamination of 1,3‐dienes has been achieved with the dinuclear catalyst ( R )‐DTBM‐SEGPHOS. The rate and selectivity of the reaction are enhanced by alcohol additives like menthol, which coordinates the cationic gold(I) to generate a Brønsted acid that can participate in catalysis. Mbs= p ‐methoxybenzenesulfonyl.
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