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Methyltransferase Activity of an Iridium Center with Methylpyridinium as Methylene Source
Author(s) -
Lalrempuia Ralte,
MüllerBunz Helge,
Albrecht Martin
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104073
Subject(s) - chemistry , iridium , methylene , nitrile , aryl , medicinal chemistry , pyridinium , pyridine , methylation , stereochemistry , organic chemistry , catalysis , dna , alkyl , biochemistry
Hop on, hop off : An iridium center transfers a methyl group from pyridinium to an aryl unit, using exclusively the pyridine‐bound methyl group as a mild methylene source. The reaction also involves cleavage of an unactivated C(aryl)H bond and nitrile solvent activation. The process is reminiscent of DNA methylation and entails the formation of two new C(sp 2 )C(sp 3 ) bonds within the metal coordination sphere (see scheme).