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Copper‐Catalyzed Trifluoromethylation of Unactivated Olefins
Author(s) -
Parsons Andrew T.,
Buchwald Stephen L.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201104053
Subject(s) - library science , citation , chemistry , computer science
Activating the inactive : A copper‐catalyzed allylic trifluoromethylation of unactivated terminal olefins proceeds under mild conditions to produce linear allylic trifluoromethylated products with high E / Z selectivity (see scheme). The reaction can be applied to a range of substrates bearing numerous functional groups. Furthermore, the reaction is scalable and amenable to a benchtop setup.