Prediction of a Ligand‐Binding Niche within a Human Olfactory Receptor by Combining Site‐Directed Mutagenesis with Dynamic Homology Modeling | Zendy

Gelis Lian | Zendy; Wolf Steffen | Zendy; Hatt Hanns | Zendy; Neuhaus Eva M. | Zendy; Gerwert Klaus | Zendy

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Prediction of a Ligand‐Binding Niche within a Human Olfactory Receptor by Combining Site‐Directed Mutagenesis with Dynamic Homology Modeling

Author(s) -

Gelis Lian,

Wolf Steffen,

Hatt Hanns,

Neuhaus Eva M.,

Gerwert Klaus

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201103980

Subject(s) - computational biology , olfactory receptor , reprogramming , niche , homology modeling , biology , mutagenesis , binding site , mutant , site directed mutagenesis , homology (biology) , receptor , evolutionary biology , genetics , neuroscience , computer science , gene , ecology , biochemistry , enzyme

Reprogramming a smell receptor : The ligand‐binding niche within a three‐dimensional model of a human olfactory receptor has been predicted by dynamic homology modeling and confirmed experimentally by functional studies of site‐directed receptor mutants. Even a proposed reprogramming of the receptor's binding and activation properties was experimentally confirmed.

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