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A Small Molecule Modulates Circadian Rhythms through Phosphorylation of the Period Protein
Author(s) -
Lee Jae Wook,
Hirota Tsuyoshi,
Peters Eric C.,
Garcia Michael,
Gonzalez Rodolfo,
Cho Charles Y.,
Wu Xu,
Schultz Peter G.,
Kay Steve A.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103915
Subject(s) - period (music) , circadian rhythm , benzothiazole , phosphorylation , small molecule , protein kinase a , computational biology , chemistry , biology , information retrieval , biochemistry , computer science , neuroscience , physics , acoustics
Time shift : A high‐throughput cell‐based screen identified a benzothiazole analogue, LH846, which induces period lengthening of the circadian rhythm. Affinity chromatography coupled with mass spectrometry and genomic analysis identified protein kinase CKIδ as the biological target of LH846 (see picture).