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The Discovery of 5‐Formylcytosine in Embryonic Stem Cell DNA
Author(s) -
Pfaffeneder Toni,
Hackner Benjamin,
Truß Matthias,
Münzel Martin,
Müller Markus,
Deiml Christian A.,
Hagemeier Christian,
Carell Thomas
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103899
Subject(s) - 5 hydroxymethylcytosine , dna demethylation , embryonic stem cell , dna , demethylation , computer science , world wide web , computational biology , information retrieval , dna methylation , biology , genetics , gene , gene expression
Touching base : Sophisticated mass spectrometry has shown that 5‐formylcytosine is a constituent of mammalian embryonic stem cell DNA. This base is likely produced from methylcytosine via hydroxymethylcytosine (see scheme), and it may serve as an intermediate in the long searched for pathway of active DNA demethylation.