Palladium‐Catalyzed Aryl Iodide Carbonylation as a Route to Imidazoline Synthesis: Design of a Five‐Component Coupling Reaction | Zendy

Bontemps Sébastien | Zendy; Quesnel Jeffrey S. | Zendy; Worrall Kraig | Zendy; Arndtsen Bruce A. | Zendy

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Palladium‐Catalyzed Aryl Iodide Carbonylation as a Route to Imidazoline Synthesis: Design of a Five‐Component Coupling Reaction

Author(s) -

Bontemps Sébastien,

Quesnel Jeffrey S.,

Worrall Kraig,

Arndtsen Bruce A.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201103885

Subject(s) - palladium , aryl , carbonylation , catalysis , iodide , chemistry , imidazoline receptor , coupling reaction , component (thermodynamics) , coupling (piping) , combinatorial chemistry , organic chemistry , carbon monoxide , materials science , medicine , pharmacology , alkyl , physics , thermodynamics , metallurgy

Take five : A new method employing aryl halide carbonylation to directly access heterocycles has been described (see scheme). In a single palladium‐catalyzed reaction the catalyst mediates two consecutive carbonylation steps, thereby converting five components (aryl iodide, two units imine, and two units CO) into an imidazoline ring.

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