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Palladium‐Catalyzed Aryl Iodide Carbonylation as a Route to Imidazoline Synthesis: Design of a Five‐Component Coupling Reaction
Author(s) -
Bontemps Sébastien,
Quesnel Jeffrey S.,
Worrall Kraig,
Arndtsen Bruce A.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103885
Subject(s) - carbonylation , aryl , palladium , iodide , catalysis , imine , halide , chemistry , component (thermodynamics) , combinatorial chemistry , imidazoline receptor , organic chemistry , carbon monoxide , physics , medicine , alkyl , thermodynamics
Take five : A new method employing aryl halide carbonylation to directly access heterocycles has been described (see scheme). In a single palladium‐catalyzed reaction the catalyst mediates two consecutive carbonylation steps, thereby converting five components (aryl iodide, two units imine, and two units CO) into an imidazoline ring.