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Metal‐Mediated Deformylation Reactions: Synthetic and Biological Avenues
Author(s) -
Patra Tuhin,
Manna Srimanta,
Maiti Debabrata
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103860
Subject(s) - oxygenate , formate , chemistry , combinatorial chemistry , organic chemistry , catalysis
No two ways about it : The title reaction is immensely important in synthesis and biology. Whereas biological systems oxygenate aldehydes to generate formate and alkanes or alkenes, synthetic deformylation reactions primarily rely on rapid oxidative addition into the C(O)H bond and subsequent rate‐determining extrusion of CO.