Premium
A Hemin/G‐Quadruplex Acts as an NADH Oxidase and NADH Peroxidase Mimicking DNAzyme
Author(s) -
Golub Eyal,
Freeman Ronit,
Willner Itamar
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103853
Subject(s) - hemin , deoxyribozyme , peroxidase , cofactor , nad+ kinase , chemistry , biochemistry , oxidase test , g quadruplex , enzyme , heme , dna
Enzyme impressionist : A DNAzyme consisting of hemin combined with a G‐quadruplex was shown to mimic the activity of NADH oxidase under aerobic conditions and of NADH peroxidase under anaerobic conditions. Along with these new biocatalytic activities, the hemin/G‐quadruplex complex is also capable of regenerating the biologically important NAD + cofactor in both cycles (see picture).