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Gold(I)‐Catalyzed Synthesis of Benzoxocines by an 8‐ endo ‐dig Cyclization
Author(s) -
Wittstein Kathrin,
Kumar Kamal,
Waldmann Herbert
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103832
Subject(s) - dig , catalysis , ring (chemistry) , chemistry , enyne , combinatorial chemistry , stereochemistry , computer science , organic chemistry , computer security
A golden dig! Gold‐catalyzed direct access to functionalized 2 H ‐1‐benzoxocines, eight‐membered‐ring ethers, is described. This unprecedented synthesis of benzoxocines occurs by an 8‐ endo‐ dig cyclization of the 1,7‐enyne substrates.