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Interlayer‐Crosslinked Micelle with Partially Hydrated Core Showing Reduction and pH Dual Sensitivity for Pinpointed Intracellular Drug Release
Author(s) -
Dai Jian,
Lin Shudong,
Cheng Du,
Zou Seyin,
Shuai Xintao
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103806
Subject(s) - dithiothreitol , micelle , drug , doxorubicin , chemistry , biophysics , combinatorial chemistry , biochemistry , pharmacology , medicine , organic chemistry , biology , enzyme , chemotherapy , surgery , aqueous solution
On the double : A highly packed interlayer‐crosslinked micelle (HP‐ICM) with pH and reduction sensitivity was developed for targeted drug release (see picture; DTT=dithiothreitol, red circles=doxorubicin). The HP‐ICM suppresses drug leakage in blood circulation while rapidly releasing drug inside lysosomes of cancer cells. Biological studies revealed the potential of the dual‐sensitive HP‐ICM in cancer treatment.