A Direct Method for Site‐Specific Protein Acetylation | Zendy

Li Fupeng | Zendy; Allahverdi Abdollah | Zendy; Yang Renliang | Zendy; Lua Gavian Bing Jia | Zendy; Zhang Xiaohong | Zendy; Cao Yuan | Zendy; Korolev Nikolay | Zendy; Nordenskiöld Lars | Zendy; Liu ChuanFa | Zendy

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A Direct Method for Site‐Specific Protein Acetylation

Author(s) -

Li Fupeng,

Allahverdi Abdollah,

Yang Renliang,

Lua Gavian Bing Jia,

Zhang Xiaohong,

Cao Yuan,

Korolev Nikolay,

Nordenskiöld Lars,

Liu ChuanFa

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201103754

Subject(s) - acetylation , thiol , radical , lysine , chemistry , stereochemistry , combinatorial chemistry , biochemistry , amino acid , gene

Radicals at work : Radical‐mediated thiol‐ene addition of the thiol group of Cys to N ‐vinylacetamide gives acetyl‐thialysine (K S Ac), a near‐perfect mimic of acetyl‐lysine (see picture). The reaction is highly efficient with near quantitative conversion obtained in short reaction times. The generated K S Ac is functionally identical or similar to its native counterpart.

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