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Electrochemical Control of Growth Factor Presentation To Steer Neural Stem Cell Differentiation
Author(s) -
Herland Anna,
Persson Kristin M.,
Lundin Vanessa,
Fahlman Mats,
Berggren Magnus,
Jager Edwin W. H.,
Teixeira Ana I.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103728
Subject(s) - pedot:pss , counterion , electrochemistry , substrate (aquarium) , bioavailability , nanotechnology , neural stem cell , conjugated system , growth factor , stem cell , chemistry , combinatorial chemistry , polymer , materials science , microbiology and biotechnology , biology , biochemistry , bioinformatics , ecology , organic chemistry , electrode , ion , receptor
Let it grow : The conjugated polymer poly(3,4‐ethylenedioxythiophene) (PEDOT) was synthesized with heparin as the counterion to form a cell culture substrate. The surface of PEDOT:heparin in the neutral state associated biologically active growth factors (see picture). Electrochemical in situ oxidation of PEDOT during live cell culture decreased the bioavailability of the growth factor and created an exact onset of neural stem cell differentiation.