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Rearrangement of 2‐Aryloxybenzaldehydes to 2‐Hydroxybenzophenones by Rhodium‐Catalyzed Cleavage of Aryloxy CO Bonds
Author(s) -
Rao Honghua,
Li ChaoJun
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103599
Subject(s) - rhodium , cleavage (geology) , nitrile , chemistry , aldehyde , aryl , catalysis , bond cleavage , halide , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , materials science , alkyl , fracture (geology) , composite material
Lost in the shuffle : An unprecedented rearrangement of the title compounds proceeds by the simultaneous rhodium‐catalyzed cleavage of aryloxy CO and aldehyde CH bonds (see scheme). The reaction tolerates the presence of various catalytically reactive substituents such as aryl halides, nitrile, and esters.