A General Method for Synthesis of GPI Anchors Illustrated by the Total Synthesis of the Low‐Molecular‐Weight Antigen from  Toxoplasma gondii | Zendy

Tsai YuHsuan | Zendy; Götze Sebastian | Zendy; Azzouz Nahid | Zendy; Hahm Heung Sik | Zendy; Seeberger Peter H. | Zendy; Varon Silva Daniel | Zendy

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A General Method for Synthesis of GPI Anchors Illustrated by the Total Synthesis of the Low‐Molecular‐Weight Antigen from Toxoplasma gondii

Author(s) -

Tsai YuHsuan,

Götze Sebastian,

Azzouz Nahid,

Hahm Heung Sik,

Seeberger Peter H.,

Varon Silva Daniel

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201103483

Subject(s) - toxoplasma gondii , glycolipid , monoclonal antibody , antigen , biology , protozoa , chemistry , antibody , immunology , microbiology and biotechnology

Building blocks : A new, general synthetic strategy, which allows the construction of branched glycosylphosphatidylinositols (GPIs), enables the synthesis of parasitic glycolipid 1 from Toxoplasma gondii. In addition, the structure is further confirmed by recognition of monoclonal antibodies.

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