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A General Method for Synthesis of GPI Anchors Illustrated by the Total Synthesis of the Low‐Molecular‐Weight Antigen from Toxoplasma gondii
Author(s) -
Tsai YuHsuan,
Götze Sebastian,
Azzouz Nahid,
Hahm Heung Sik,
Seeberger Peter H.,
Varon Silva Daniel
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103483
Subject(s) - toxoplasma gondii , glycolipid , monoclonal antibody , antigen , biology , protozoa , chemistry , antibody , immunology , microbiology and biotechnology
Building blocks : A new, general synthetic strategy, which allows the construction of branched glycosylphosphatidylinositols (GPIs), enables the synthesis of parasitic glycolipid 1 from Toxoplasma gondii. In addition, the structure is further confirmed by recognition of monoclonal antibodies.