Polarity‐Switching Electrochemical Sensor for Specific Detection of Single‐Nucleotide Mismatches | Zendy

Hsieh Kuangwen | Zendy; White Ryan J. | Zendy; Ferguson Brian S. | Zendy; Plaxco Kevin W. | Zendy; Xiao Yi | Zendy; Soh H. Tom | Zendy

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Polarity‐Switching Electrochemical Sensor for Specific Detection of Single‐Nucleotide Mismatches

Author(s) -

Hsieh Kuangwen,

White Ryan J.,

Ferguson Brian S.,

Plaxco Kevin W.,

Xiao Yi,

Soh H. Tom

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201103482

Subject(s) - polarity (international relations) , methylene blue , nucleotide , electrochemistry , chemistry , current (fluid) , redox , materials science , analytical chemistry (journal) , nanotechnology , electrode , biochemistry , physics , inorganic chemistry , gene , chromatography , thermodynamics , photocatalysis , cell , catalysis

Getting a response : A surface‐bound and redox‐modified (methylene blue) DNA probe architecture is at the heart of a sensor for detecting single‐nucleotide mismatched targets with a “polarity‐switching” response. It outputs a decreased Faradaic current when hybridized to a perfectly matched (PM) target, and an increased Faradaic current when hybridized to a single‐base mismatched (SM) target (see scheme).

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