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An Acyclic Oligoheteroaryle That Discriminates Strongly between Diverse G‐Quadruplex Topologies
Author(s) -
Hamon Florian,
Largy Eric,
GuédinBeaurepaire Aurore,
RouchonDagois Myriam,
Sidibe Assitan,
Monchaud David,
Mergny JeanLouis,
Riou JeanFrancois,
Nguyen ChiHung,
TeuladeFichou MariePaule
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103422
Subject(s) - g quadruplex , oxazole , network topology , binding affinities , computer science , derivative (finance) , ligand (biochemistry) , stereochemistry , computational biology , chemistry , combinatorial chemistry , biology , dna , biochemistry , computer network , receptor , financial economics , economics
Feeling groovy : A family of nonmacrocyclic G‐quadruplex binders with alternate oxazole and pyridine motifs was prepared. The shown heptacyclic derivative exhibits an unprecedented binding preference for certain quadruplex topologies: it recognizes exclusively the human telomeric quadruplex in Na + buffer but not in K + buffer. This unique quadruplex binding profile is strongly dependent on the size of the ligand and may result from groove interactions.