An Acyclic Oligoheteroaryle That Discriminates Strongly between Diverse G‐Quadruplex Topologies | Zendy

Hamon Florian | Zendy; Largy Eric | Zendy; GuédinBeaurepaire Aurore | Zendy; RouchonDagois Myriam | Zendy; Sidibe Assitan | Zendy; Monchaud David | Zendy; Mergny JeanLouis | Zendy; Riou JeanFrancois | Zendy; Nguyen ChiHung | Zendy; TeuladeFichou MariePaule | Zendy

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An Acyclic Oligoheteroaryle That Discriminates Strongly between Diverse G‐Quadruplex Topologies

Author(s) -

Hamon Florian,

Largy Eric,

GuédinBeaurepaire Aurore,

RouchonDagois Myriam,

Sidibe Assitan,

Monchaud David,

Mergny JeanLouis,

Riou JeanFrancois,

Nguyen ChiHung,

TeuladeFichou MariePaule

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201103422

Subject(s) - g quadruplex , oxazole , network topology , binding affinities , computer science , computational biology , chemistry , stereochemistry , combinatorial chemistry , biology , dna , biochemistry , computer network , receptor

Feeling groovy : A family of nonmacrocyclic G‐quadruplex binders with alternate oxazole and pyridine motifs was prepared. The shown heptacyclic derivative exhibits an unprecedented binding preference for certain quadruplex topologies: it recognizes exclusively the human telomeric quadruplex in Na + buffer but not in K + buffer. This unique quadruplex binding profile is strongly dependent on the size of the ligand and may result from groove interactions.

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