Premium
More Radical Magic with B 12 : B 12 ‐Catalyzed, Light‐Induced Cleavage of DNA
Author(s) -
Kräutler Bernhard,
Puffer Barbara
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103373
Subject(s) - radical , cleavage (geology) , photochemistry , catalysis , dna , chemistry , magic (telescope) , visible spectrum , materials science , physics , optoelectronics , organic chemistry , biochemistry , quantum mechanics , fracture (geology) , composite material
B 12 in a new light : The B 12 derivative hydroxocobalamin can be used as an efficient catalyst for light‐induced strand cleavage of DNA. The proposed radical process involves hydroxy radicals and is controlled by visible light (see scheme). Such light‐controlled radical reactions promise to be particularly useful in intracellular applications.