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Dynamic Kinetic Resolution of α‐Substituted β‐Ketoesters Catalyzed by Baeyer–Villiger Monooxygenases: Access to Enantiopure α‐Hydroxy Esters
Author(s) -
RiozMartínez Ana,
Cuetos Aníbal,
Rodríguez Cristina,
de Gonzalo Gonzalo,
Lavandera Iván,
Fraaije Marco W.,
Gotor Vicente
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103348
Subject(s) - kinetic resolution , enantiopure drug , monooxygenase , chemistry , catalysis , alkyl , baeyer–villiger oxidation , biocatalysis , resolution (logic) , organic chemistry , stereochemistry , combinatorial chemistry , enantioselective synthesis , enzyme , reaction mechanism , cytochrome p450 , computer science , artificial intelligence
BVMOs make a play : The dynamic kinetic resolution of racemic α‐alkyl‐β‐ketoesters was performed through a selective Baeyer–Villiger oxidation employing different Baeyer–Villiger monooxygenases (BVMOs) in mild basic media. The product diesters were obtained with excellent yields and enantioselectivities, and used as precursors for optically active α‐hydroxy esters.