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Control of Circadian Phase by an Artificial Zinc Finger Transcription Regulator
Author(s) -
Imanishi Miki,
Nakamura Atsushi,
Doi Masao,
Futaki Shiroh,
Okamura Hitoshi
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103307
Subject(s) - zinc finger , circadian rhythm , circadian clock , transcription (linguistics) , regulator , microbiology and biotechnology , oscillating gene , phase control , master regulator , lim domain , biology , transcription factor , chemistry , biophysics , neuroscience , biochemistry , bacterial circadian rhythms , phase (matter) , gene , linguistics , philosophy , organic chemistry
I got rhythm : The circadian clock is driven by transcription–translation feedback loops. The circadian time can be altered by creating an artificial zinc finger protein specifically binding to the glucocorticoid responsive element (GRE) on the Period1 promoter (see picture; DD=destabilizing domain, AD=activation domain). This artificial protein directly controls the clock machinery.