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Diversity‐Oriented Production of Metabolites Derived from Chorismate and Their Use in Organic Synthesis
Author(s) -
Bongaerts Johannes,
Esser Simon,
Lorbach Volker,
AlMomani Lóay,
Müller Michael A.,
Franke Dirk,
Grondal Christoph,
Kurutsch Anja,
Bujnicki Robert,
Takors Ralf,
Raeven Leon,
Wubbolts Marcel,
Bovenberg Roel,
Nieger Martin,
Schürmann Melanie,
Trachtmann Natalie,
Kozak Stefan,
Sprenger Georg A.,
Müller Michael
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103261
Subject(s) - bioproduction , shikimate pathway , metabolic engineering , metabolic pathway , biosynthesis , chemistry , biochemistry , biochemical engineering , metabolism , enzyme , engineering
Biosynthesis as a model : Based on the branched structure of biosynthetic pathways, such as the shikimate pathway, the selective bioproduction of a set of diverse metabolites has been achieved by means of metabolic engineering (see scheme). A scale‐up for preparative purposes was performed, resulting in high product titers and yields from renewable resources.