Chiral Phosphoric Acid Catalyzed Transfer Hydrogenation: Facile Synthetic Access to Highly Optically Active Trifluoromethylated Amines | Zendy

Henseler Alexander | Zendy; Kato Masanori | Zendy; Mori Keiji | Zendy; Akiyama Takahiko | Zendy

Premium

Chiral Phosphoric Acid Catalyzed Transfer Hydrogenation: Facile Synthetic Access to Highly Optically Active Trifluoromethylated Amines

Author(s) -

Henseler Alexander,

Kato Masanori,

Mori Keiji,

Akiyama Takahiko

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201103240

Subject(s) - reductive amination , optically active , transfer hydrogenation , catalysis , chemistry , combinatorial chemistry , amination , phosphoric acid , organic chemistry , ruthenium

Amines to an end : Highly optically active α ‐ CF 3 ‐functionalized amines can be obtained using metal‐free reaction conditions. The method involves the transfer hydrogenation of CF 3 ‐substituted ketimines catalyzed by 1 and reductive amination of CF 3 ‐substituted ketones. The synthetic utility of this method was demonstrated by the synthesis of a CF 3 analogue of NPS R‐568. PMP= para ‐methoxyphenyl.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research