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Chiral Phosphoric Acid Catalyzed Transfer Hydrogenation: Facile Synthetic Access to Highly Optically Active Trifluoromethylated Amines
Author(s) -
Henseler Alexander,
Kato Masanori,
Mori Keiji,
Akiyama Takahiko
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103240
Subject(s) - reductive amination , optically active , transfer hydrogenation , catalysis , chemistry , combinatorial chemistry , amination , phosphoric acid , organic chemistry , ruthenium
Amines to an end : Highly optically active α ‐ CF 3 ‐functionalized amines can be obtained using metal‐free reaction conditions. The method involves the transfer hydrogenation of CF 3 ‐substituted ketimines catalyzed by 1 and reductive amination of CF 3 ‐substituted ketones. The synthetic utility of this method was demonstrated by the synthesis of a CF 3 analogue of NPS R‐568. PMP= para ‐methoxyphenyl.