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Silver‐Catalyzed Intramolecular Aminofluorination of Activated Allenes
Author(s) -
Xu Tao,
Mu Xin,
Peng Haihui,
Liu Guosheng
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103225
Subject(s) - intramolecular force , reagent , catalysis , chemistry , combinatorial chemistry , pyrrole , transformation (genetics) , scheme (mathematics) , computer science , organic chemistry , mathematics , biochemistry , gene , mathematical analysis
A nice combination : The intramolecular oxidative aminofluorination of allenes using silver catalysis and FN(SO 2 Ph) 2 as the fluorinating reagent has been developed. This reaction represents an efficient method for the synthesis of various 4‐fluoro‐2,5‐dihydropyrrole compounds. Further transformation provided the corresponding fluorinated pyrrole derivatives in good yields (see scheme).