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A Highly Active Catalyst for the Hydrogenation of Amides to Alcohols and Amines
Author(s) -
John Jeremy M.,
Bergens Steven H.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103137
Subject(s) - catalysis , amide , yield (engineering) , chemistry , reagent , hydride , organic chemistry , atom economy , catalytic hydrogenation , metal , combinatorial chemistry , materials science , metallurgy
Amide‐zing : The reaction between 2 equivalents of Ph 2 P(CH 2 ) 2 NH 2 and cis ‐[Ru(CH 3 CN) 2 (η 3 ‐C 3 H 5 )(cod)]BF 4 (cod=1,5‐cyclooctadiene) forms a highly active catalyst precursor for the selective hydrogenation of amides. The reaction proceeds with excellent atom economy, yield, and turnover numbers (TONs) under moderate reaction conditions. The technology offers a greener, practical approach to the use of metal hydride reagents commonly employed in both academia and industry.