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Synthetic Polymers for Simultaneous Bacterial Sequestration and Quorum Sense Interference
Author(s) -
Xue Xuan,
Pasparakis George,
Halliday Nigel,
Winzer Klaus,
Howdle Steven M.,
Cramphorn Christopher J.,
Cameron Neil R.,
Gardner Paul M.,
Davis Benjamin G.,
FernándezTrillo Francisco,
Alexander Cameron
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103130
Subject(s) - quorum sensing , vibrio harveyi , bioluminescence , vibrio , sense (electronics) , chemistry , quorum quenching , computational biology , computer science , biology , biochemistry , bacteria , gene , virulence , genetics
Double agents : Dual‐action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals (see picture). The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence.