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Concise Syntheses of Strychnine and Englerin A: the Power of Reductive Cyclizations Triggered by Samarium Iodide
Author(s) -
Szostak Michal,
Procter David J.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103128
Subject(s) - strychnine , reagent , chemistry , samarium , iodide , alkaloid , combinatorial chemistry , organic chemistry , biochemistry
Electronica : Spectacular cyclization reactions mediated by the electron‐transfer reagent samarium diiodide (Kagan's reagent) were instrumental in efficient syntheses of the classic alkaloid strychnine and the recently discovered guaiane sesquiterpene, englerin A (see picture).