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Urchin‐Shaped Manganese Oxide Nanoparticles as pH‐Responsive Activatable T 1 Contrast Agents for Magnetic Resonance Imaging
Author(s) -
Kim Taekhoon,
Cho EunJin,
Chae Youngjoo,
Kim Minsik,
Oh Aram,
Jin Juhong,
Lee EunSook,
Baik Hionsuck,
Haam Seungjoo,
Suh JinSuck,
Huh YongMin,
Lee Kwangyeol
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103108
Subject(s) - manganese , nanoparticle , contrast (vision) , magnetic resonance imaging , manganese oxide , nuclear magnetic resonance , resonance (particle physics) , materials science , nanotechnology , chemistry , computer science , physics , medicine , artificial intelligence , radiology , organic chemistry , particle physics
Image enhancement : Core–shell MnO@Mn 3 O 4 urchin‐shaped nanoparticles can be synthesized by means of an anisotropic etching process and used as a pH‐activatable T 1 contrast agent for magnetic resonance imaging. The manganese ions released from the MnO phase in the low‐pH sites within tumor cells lead to an enhanced T 1 contrast image for the entire tumor mass.