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Transcriptome Mining of Active Biosynthetic Pathways and Their Associated Products in Streptomyces flaveolus
Author(s) -
Qu Xudong,
Lei Chun,
Liu Wen
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103085
Subject(s) - transcriptome , genome , computational biology , streptomyces , natural product , information retrieval , natural (archaeology) , biology , computer science , world wide web , gene , genetics , gene expression , biochemistry , paleontology , bacteria
Missing link : Biosynthetic pathways and the production of related (known and unknown) natural products can be probed at the transcriptional level in Streptomyces flaveolus by a transcriptome‐screening strategy (see picture). The approach complements recent advances in genome mining and potentially benefits natural product discovery from strains whose genomes have not been sequenced.