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Practical One‐Pot Preparation of Magnesium Di(hetero)aryl‐ and Magnesium Dialkenylboronates for Suzuki–Miyaura Cross‐Coupling Reactions
Author(s) -
Haag Benjamin A.,
Sämann Christoph,
Jana Anukul,
Knochel Paul
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103022
Subject(s) - aryl , magnesium , halide , chemistry , combinatorial chemistry , coupling reaction , atom (system on chip) , database , organic chemistry , catalysis , computer science , alkyl , embedded system
Mg for B : An atom‐economical one‐pot synthesis by direct magnesium insertion in the presence of B(OBu) 3 and LiCl allows a broad range of functionalized (hetero)aryl and alkenyl bromides to be converted into magnesium diorganoboronates 2 , which undergo Suzuki–Miyaura cross‐coupling reactions with various aryl (pseudo)halides (see scheme). Both aryl groups of 2 are transferred and furnish the products in good to excellent yields.