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Impact of Strand Length on the Stability of Parallel‐β‐Sheet Secondary Structure
Author(s) -
Freire Felix,
Almeida Aaron M.,
Fisk John D.,
Steinkruger Jay D.,
Gellman Samuel H.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102986
Subject(s) - subject (documents) , computer science , stability (learning theory) , beta sheet , single strand , information retrieval , inclusion (mineral) , chemistry , world wide web , protein structure , biochemistry , dna , mineralogy , machine learning
Molecular design can be used to investigate whether the parallel‐β‐sheet secondary structure is subject to length‐dependent cooperative stabilization along the strand direction (see picture). Extending strands by adding high‐propensity residues (B) leads to a steady increase in parallel‐β‐sheet stability, but inclusion of low‐propensity residues (A) can negate this stabilization.