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Palladium(II)‐Catalyzed Selective Monofluorination of Benzoic Acids Using a Practical Auxiliary: A Weak‐Coordination Approach
Author(s) -
Chan Kelvin S. L.,
Wasa Masayuki,
Wang Xisheng,
Yu JinQuan
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102985
Subject(s) - palladium , benzoic acid , catalysis , combinatorial chemistry , trifluoromethyl , chemistry , scheme (mathematics) , simple (philosophy) , computer science , organic chemistry , mathematics , philosophy , mathematical analysis , epistemology , alkyl
Finally, a choice! A highly selective palladium(II)‐catalyzed ortho ‐monofluorination reaction has been achieved for the first time through a weak coordination (see scheme; Ar=2,3,5,6‐tetrafluoro‐4‐(trifluoromethyl)phenyl). Simple modification of this protocol allows for a choice between mono‐ and difluorination. The mono‐ and difluorinated benzoic acid derivatives are valuable in the pharmaceutical and agrochemical industries.