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Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras‐Signaling Modulators Palmostatin B and M
Author(s) -
Rusch Marion,
Zimmermann Tobias J.,
Bürger Marco,
Dekker Frank J.,
Görmer Kristina,
Triola Gemma,
Brockmeyer Andreas,
Janning Petra,
Böttcher Thomas,
Sieber Stephan A.,
Vetter Ingrid R.,
Hedberg Christian,
Waldmann Herbert
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102967
Subject(s) - thioesterase , signal transduction , chemistry , identification (biology) , biochemistry , microbiology and biotechnology , biology , computational biology , enzyme , biosynthesis , botany
Finding the target : Activity‐based proteomic profiling probes based on the depalmitoylation inhibitors palmostatin B and M (see picture) have been synthesized and were found to target acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells.