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Detection of DNA–Ligand Binding Oscillations by Stokes‐Shift Measurements
Author(s) -
Sajadi Mohsen,
Furse Kristina E.,
Zhang XinXing,
Dehmel Lars,
Kovalenko Sergey A.,
Corcelli Steven A.,
Ernsting Nikolaus P.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102942
Subject(s) - oscillation (cell signaling) , ligand (biochemistry) , ripple , minor groove , groove (engineering) , motion (physics) , dna , computer science , content (measure theory) , stokes shift , physics , information retrieval , biophysics , chemistry , optics , biology , computer vision , mathematics , receptor , mathematical analysis , engineering , thermodynamics , biochemistry , mechanical engineering , power (physics) , luminescence
Riding the waves : In a DNA–ligand complex, the time‐dependent Stokes shift shows initial oscillation. Molecular dynamics simulations help assign this ripple to coherent in/out motion of the ligand together with breathing of the minor groove (see picture).