Nanostructured Immunosensor for Attomolar Detection of Cancer Biomarker Interleukin‐8 Using Massively Labeled Superparamagnetic Particles | Zendy

Munge Bernard S. | Zendy; Coffey Amy L. | Zendy; Doucette Jaimee M. | Zendy; Somba Brian K. | Zendy; Malhotra Ruchika | Zendy; Patel Vyomesh | Zendy; Gutkind J. Silvio | Zendy; Rusling James F. | Zendy

Premium

Nanostructured Immunosensor for Attomolar Detection of Cancer Biomarker Interleukin‐8 Using Massively Labeled Superparamagnetic Particles

Author(s) -

Munge Bernard S.,

Coffey Amy L.,

Doucette Jaimee M.,

Somba Brian K.,

Malhotra Ruchika,

Patel Vyomesh,

Gutkind J. Silvio,

Rusling James F.

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201102941

Subject(s) - superparamagnetism , horseradish peroxidase , conjugate , chemistry , biomarker , nanotechnology , nanoparticle , magnetic nanoparticles , materials science , organic chemistry , magnetization , biochemistry , enzyme , physics , quantum mechanics , magnetic field , mathematical analysis , mathematics

A sensitive issue : Superparamagnetic particle–antibody conjugates enable detection of interleukin‐8 (IL‐8) in serum at a level of 1 fg mL −1 (ca. 100 a M ). Ultrahigh sensitivity is facilitated by a nanostructured sensor platform coupled with secondary antibody–magnetic bead–horseradish peroxidase conjugate (Ab 2 –MB–HRP) with about 500 000 HRP labels (see picture).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research