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Tumor‐Targeting Gold Particles for Dual Computed Tomography/Optical Cancer Imaging
Author(s) -
Sun InCheol,
Eun DaeKyung,
Koo Heebeom,
Ko ChangYong,
Kim HanSung,
Yi Dong Kee,
Choi Kuiwon,
Kwon Ick Chan,
Kim Kwangmeyung,
Ahn CheolHee
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102892
Subject(s) - colloidal gold , computed tomography , fluorescence , nanotechnology , nanoparticle , matrix metalloproteinase , matrix (chemical analysis) , materials science , computer science , chemistry , radiology , medicine , optics , physics , biochemistry , composite material
Double spotlight : A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical imaging exhibits have been developed (see picture). The excellent stability, tumor targeting ability, enhanced X‐ray absorption, and matrix metalloproteinase (MMP) activatable fluorescence recovery was achieved by surface modification of AuNPs with glycol chitosan and fluorescent MMP peptide probes.