Smart Multifunctional Hollow Microspheres for the Quick Release of Drugs in Intracellular Lysosomal Compartments | Zendy

Ke CherngJyh | Zendy; Su TzuYuan | Zendy; Chen HsinLung | Zendy; Liu HaoLi | Zendy; Chiang WeiLun | Zendy; Chu PoChun | Zendy; Xia Younan | Zendy; Sung HsingWen | Zendy

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Smart Multifunctional Hollow Microspheres for the Quick Release of Drugs in Intracellular Lysosomal Compartments

Author(s) -

Ke CherngJyh,

Su TzuYuan,

Chen HsinLung,

Liu HaoLi,

Chiang WeiLun,

Chu PoChun,

Xia Younan,

Sung HsingWen

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201102852

Subject(s) - plga , microsphere , endocytic cycle , glycolic acid , chemistry , intracellular , aqueous solution , lactic acid , biophysics , organelle , chemical engineering , endocytosis , nanotechnology , materials science , cell , biochemistry , organic chemistry , in vitro , biology , genetics , bacteria , engineering

Prepared to self‐destruct : When poly( d,l ‐lactic‐ co ‐glycolic acid) (PLGA) hollow microspheres containing NaHCO 3 entered the endocytic organelles of a live cell, the NaHCO 3 in the aqueous core reacted with protons that infiltrated from the compartment to generate CO 2 gas. The evolution of CO 2 bubbles led to the formation of small holes in the PLGA shell and thus rapid release of the encapsulated drug doxorubicin (DOX; see picture).

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