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Smart Multifunctional Hollow Microspheres for the Quick Release of Drugs in Intracellular Lysosomal Compartments
Author(s) -
Ke CherngJyh,
Su TzuYuan,
Chen HsinLung,
Liu HaoLi,
Chiang WeiLun,
Chu PoChun,
Xia Younan,
Sung HsingWen
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102852
Subject(s) - plga , microsphere , endocytic cycle , glycolic acid , chemistry , intracellular , aqueous solution , lactic acid , biophysics , organelle , chemical engineering , endocytosis , nanotechnology , materials science , cell , biochemistry , organic chemistry , in vitro , biology , genetics , bacteria , engineering
Prepared to self‐destruct : When poly( d,l ‐lactic‐ co ‐glycolic acid) (PLGA) hollow microspheres containing NaHCO 3 entered the endocytic organelles of a live cell, the NaHCO 3 in the aqueous core reacted with protons that infiltrated from the compartment to generate CO 2 gas. The evolution of CO 2 bubbles led to the formation of small holes in the PLGA shell and thus rapid release of the encapsulated drug doxorubicin (DOX; see picture).