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Artificial Molecular Clamp: A Novel Device for Synthetic Polymerases
Author(s) -
Takashima Yoshinori,
Osaki Motofumi,
Ishimaru Yoshihiro,
Yamaguchi Hiroyasu,
Harada Akira
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102834
Subject(s) - moiety , polymerization , polymerase , supramolecular chemistry , dimer , chemistry , polymer , combinatorial chemistry , catalysis , yield (engineering) , stereochemistry , dna , materials science , biochemistry , organic chemistry , molecule , metallurgy
Synthetic polymerases composed of a cyclodextrin (CD) dimer yield high‐molecular‐weight polymers of cyclic esters without using solvents and co‐catalysts. One CD moiety is attached to the active site of a supramolecular catalyst and propagates the polymerization by serving as artificial molecular clamp (see picture). The other CD moiety initiates the ring‐opening polymerization.