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Self‐Sorting of Dynamic Imine Libraries during Distillation
Author(s) -
Osowska Karolina,
Miljanić Ognjen Š.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102813
Subject(s) - imine , sorting , distillation , computer science , amine gas treating , yield (engineering) , aldehyde , process (computing) , chemistry , simple (philosophy) , combinatorial chemistry , organic chemistry , programming language , materials science , philosophy , catalysis , epistemology , metallurgy
Keep it simple : The reaction of n aldehydes with n amines leads to a dynamic library of [ n × n ] imines. Slow distillation of the library amplifies the most volatile imine, whereby the most volatile aldehyde and amine are extracted from all other library components. Iterative repetition of the process enabled the self‐sorting of the dynamic library into n mechanically separated imines, which were obtained in high yield.