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Finely Tuned Temperature‐Controlled Cargo Release Using Paraffin‐Capped Mesoporous Silica Nanoparticles
Author(s) -
Aznar Elena,
Mondragón Laura,
RosLis José V.,
Sancenón Félix,
Marcos M. Dolores,
MartínezMáñez Ramón,
Soto Juan,
PérezPayá Enrique,
Amorós Pedro
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102756
Subject(s) - mesoporous silica , nanoparticle , chemical engineering , mesoporous material , alkyl , layer (electronics) , materials science , fluorescence , particle (ecology) , molecule , nanotechnology , polymer chemistry , chemistry , organic chemistry , catalysis , physics , oceanography , quantum mechanics , geology , engineering
Trapped : Mesoporous silica nanoparticles were loaded with a fluorescent guest and functionalized with octadecyltrimethoxysilane. The alkyl chains interact with paraffins, which build a hydrophobic layer around the particle (see picture). Upon melting of the paraffin, the guest molecule is released, as demonstrated in cells for the guest doxorubicin. The release temperature can be tuned by choosing an appropriate paraffin.