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Fused Indolines by Palladium‐Catalyzed Asymmetric CC Coupling Involving an Unactivated Methylene Group
Author(s) -
Nakanishi Masafumi,
Katayev Dmitry,
Besnard Céline,
Kündig E. Peter
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201102639
Subject(s) - palladium , methylene , catalysis , chemistry , selectivity , coupling (piping) , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , materials science , metallurgy
Selectivity at high temperatures : Bulky, thermally stable, chiral palladium complexes generated from N‐heterocyclic carbenes (NHCs; see picture) were successfully applied to the synthesis of highly enantioenriched trans‐ fused indolines. Remarkably, this reaction occurs at elevated temperatures with excellent asymmetric recognition of an enantiotopic CH bond in an unactivated methylene unit.